Residence, Clinical Features, and Genetic Risk Factors Associated with Symptoms of COVID-19 in a Cohort of Older People in Madrid.
Identifieur interne : 000013 ( Main/Exploration ); précédent : 000012; suivant : 000014Residence, Clinical Features, and Genetic Risk Factors Associated with Symptoms of COVID-19 in a Cohort of Older People in Madrid.
Auteurs : Teodoro Del Ser [Espagne] ; Miguel A. Fernández-Blázquez [Espagne] ; Meritxell Valentí [Espagne] ; María Ascensi N Zea-Sevilla [Espagne] ; Belén Frades [Espagne] ; Eva Alfayate [Espagne] ; Laura Saiz [Espagne] ; Olga Calero [Espagne] ; Fernando José García-L Pez [Espagne] ; Alberto Rábano [Espagne] ; Miguel Medina [Espagne] ; Miguel Calero [Espagne]Source :
- Gerontology [ 1423-0003 ] ; 2021.
Abstract
BACKGROUND
The older population has been especially affected by the severe acute respiratory syndrome coronavirus 2 pandemic (COVID-19).
OBJECTIVE
The aim of the study was to explore the incidence, severity, mortality rate, clinical features, and risk factors of symptoms of COVID-19 in home-dwelling older people, and its association with type of residence, cognitive deterioration, and neurodegenerative diseases.
METHODS
Data about symptoms of COVID-19 were collected through a telephone survey in the cohort of 913 older volunteers of the Vallecas Project, aged 75-90 years, most of them (902) home-dwelling, in Madrid, Spain. The association of demographic and anthropometric measures, genetic polymorphisms, comorbidities, life habits, type of residence, and frailty surrogates were explored as potential risk factors for the incidence, severity, and mortality of COVID-19 in the older population.
FINDINGS
Sixty-two cases reported symptoms compatible with COVID-19; 6 of them had died, 4 in their home and 2 in the nursing home. Moderate/severe cases were significantly older and more frequently males. The APOE ε4 allele was associated with the presence of symptoms of COVID-19. Higher systolic blood pressure, more intense smoking habit, more alcohol intake, lower consumption of coffee and tea, and cognitive impairment were associated with disease severity.
CONCLUSIONS
The estimated incidence of symptomatic COVID-19 in this older cohort of Madrid was 6.8%, with an overall mortality rate of 0.7% (18.2% in those living in a nursing home) and a fatality rate of 9.9%. Our exploratory study indicates that life habits, other clinical conditions and, the ε4 variant of the APOE gene are associated with the presence and clinical severity of coronavirus infection.
DOI: 10.1159/000513182
PubMed: 33429394
Affiliations:
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Carlos III, Madrid, Spain, mcalero@fundacioncien.es.</nlm:affiliation><country wicri:rule="url">Espagne</country><wicri:regionArea>Centro de Investigación Biomédica en Red sobre Enfermedades Degenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain</wicri:regionArea><wicri:noRegion>Spain</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Chronic Disease Program, Institute of Health Carlos III, Madrid, Spain, mcalero@fundacioncien.es.</nlm:affiliation><country wicri:rule="url">Espagne</country><wicri:regionArea>Chronic Disease Program, Institute of Health Carlos III, Madrid, Spain</wicri:regionArea><wicri:noRegion>Spain</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2021">2021</date><idno type="RBID">pubmed:33429394</idno><idno type="pmid">33429394</idno><idno type="doi">10.1159/000513182</idno><idno type="wicri:Area/Main/Corpus">000022</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000022</idno><idno type="wicri:Area/Main/Curation">000022</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000022</idno><idno type="wicri:Area/Main/Exploration">000022</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Residence, Clinical Features, and Genetic Risk Factors Associated with Symptoms of COVID-19 in a Cohort of Older People in Madrid.</title><author><name sortKey="Del Ser, Teodoro" sort="Del Ser, Teodoro" uniqKey="Del Ser T" first="Teodoro" last="Del Ser">Teodoro Del Ser</name><affiliation wicri:level="3"><nlm:affiliation>Alzheimer's Disease Investigation Research Unit, CIEN Foundation, Institute of Health Carlos III, Queen Sofia Foundation Alzheimer Research Center, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Alzheimer's Disease Investigation Research Unit, CIEN Foundation, Institute of Health Carlos III, Queen Sofia Foundation Alzheimer Research Center, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Fernandez Blazquez, Miguel A" sort="Fernandez Blazquez, Miguel A" uniqKey="Fernandez Blazquez M" first="Miguel A" last="Fernández-Blázquez">Miguel A. Fernández-Blázquez</name><affiliation wicri:level="3"><nlm:affiliation>Alzheimer's Disease Investigation Research Unit, CIEN Foundation, Institute of Health Carlos III, Queen Sofia Foundation Alzheimer Research Center, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Alzheimer's Disease Investigation Research Unit, CIEN Foundation, Institute of Health Carlos III, Queen Sofia Foundation Alzheimer Research Center, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Valenti, Meritxell" sort="Valenti, Meritxell" uniqKey="Valenti M" first="Meritxell" last="Valentí">Meritxell Valentí</name><affiliation wicri:level="3"><nlm:affiliation>Alzheimer's Disease Investigation Research Unit, CIEN Foundation, Institute of Health Carlos III, Queen Sofia Foundation Alzheimer Research Center, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Alzheimer's Disease Investigation Research Unit, CIEN Foundation, Institute of Health Carlos III, Queen Sofia Foundation Alzheimer Research Center, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Zea Sevilla, Maria Ascensi N" sort="Zea Sevilla, Maria Ascensi N" uniqKey="Zea Sevilla M" first="María Ascensi N" last="Zea-Sevilla">María Ascensi N Zea-Sevilla</name><affiliation wicri:level="3"><nlm:affiliation>Alzheimer's Disease Investigation Research Unit, CIEN Foundation, Institute of Health Carlos III, Queen Sofia Foundation Alzheimer Research Center, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Alzheimer's Disease Investigation Research Unit, CIEN Foundation, Institute of Health Carlos III, Queen Sofia Foundation Alzheimer Research Center, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Frades, Belen" sort="Frades, Belen" uniqKey="Frades B" first="Belén" last="Frades">Belén Frades</name><affiliation wicri:level="3"><nlm:affiliation>Alzheimer's Disease Investigation Research Unit, CIEN Foundation, Institute of Health Carlos III, Queen Sofia Foundation Alzheimer Research Center, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Alzheimer's Disease Investigation Research Unit, CIEN Foundation, Institute of Health Carlos III, Queen Sofia Foundation Alzheimer Research Center, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Alfayate, Eva" sort="Alfayate, Eva" uniqKey="Alfayate E" first="Eva" last="Alfayate">Eva Alfayate</name><affiliation wicri:level="3"><nlm:affiliation>Alzheimer's Disease Investigation Research Unit, CIEN Foundation, Institute of Health Carlos III, Queen Sofia Foundation Alzheimer Research Center, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Alzheimer's Disease Investigation Research Unit, CIEN Foundation, Institute of Health Carlos III, Queen Sofia Foundation Alzheimer Research Center, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Saiz, Laura" sort="Saiz, Laura" uniqKey="Saiz L" first="Laura" last="Saiz">Laura Saiz</name><affiliation wicri:level="3"><nlm:affiliation>Alzheimer's Disease Investigation Research Unit, CIEN Foundation, Institute of Health Carlos III, Queen Sofia Foundation Alzheimer Research Center, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Alzheimer's Disease Investigation Research Unit, CIEN Foundation, Institute of Health Carlos III, Queen Sofia Foundation Alzheimer Research Center, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Calero, Olga" sort="Calero, Olga" uniqKey="Calero O" first="Olga" last="Calero">Olga Calero</name><affiliation wicri:level="3"><nlm:affiliation>Centro de Investigación Biomédica en Red sobre Enfermedades Degenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigación Biomédica en Red sobre Enfermedades Degenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Chronic Disease Program, Institute of Health Carlos III, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Chronic Disease Program, Institute of Health Carlos III, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Garcia L Pez, Fernando Jose" sort="Garcia L Pez, Fernando Jose" uniqKey="Garcia L Pez F" first="Fernando José" last="García-L Pez">Fernando José García-L Pez</name><affiliation wicri:level="3"><nlm:affiliation>National Epidemiology Centre, Institute of Health Carlos III, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>National Epidemiology Centre, Institute of Health Carlos III, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Rabano, Alberto" sort="Rabano, Alberto" uniqKey="Rabano A" first="Alberto" last="Rábano">Alberto Rábano</name><affiliation wicri:level="3"><nlm:affiliation>Alzheimer's Disease Investigation Research Unit, CIEN Foundation, Institute of Health Carlos III, Queen Sofia Foundation Alzheimer Research Center, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Alzheimer's Disease Investigation Research Unit, CIEN Foundation, Institute of Health Carlos III, Queen Sofia Foundation Alzheimer Research Center, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Medina, Miguel" sort="Medina, Miguel" uniqKey="Medina M" first="Miguel" last="Medina">Miguel Medina</name><affiliation wicri:level="3"><nlm:affiliation>Alzheimer's Disease Investigation Research Unit, CIEN Foundation, Institute of Health Carlos III, Queen Sofia Foundation Alzheimer Research Center, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Alzheimer's Disease Investigation Research Unit, CIEN Foundation, Institute of Health Carlos III, Queen Sofia Foundation Alzheimer Research Center, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Centro de Investigación Biomédica en Red sobre Enfermedades Degenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigación Biomédica en Red sobre Enfermedades Degenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Calero, Miguel" sort="Calero, Miguel" uniqKey="Calero M" first="Miguel" last="Calero">Miguel Calero</name><affiliation wicri:level="1"><nlm:affiliation>Alzheimer's Disease Investigation Research Unit, CIEN Foundation, Institute of Health Carlos III, Queen Sofia Foundation Alzheimer Research Center, Madrid, Spain, mcalero@fundacioncien.es.</nlm:affiliation><country wicri:rule="url">Espagne</country><wicri:regionArea>Alzheimer's Disease Investigation Research Unit, CIEN Foundation, Institute of Health Carlos III, Queen Sofia Foundation Alzheimer Research Center, Madrid, Spain</wicri:regionArea><wicri:noRegion>Spain</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Centro de Investigación Biomédica en Red sobre Enfermedades Degenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain, mcalero@fundacioncien.es.</nlm:affiliation><country wicri:rule="url">Espagne</country><wicri:regionArea>Centro de Investigación Biomédica en Red sobre Enfermedades Degenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain</wicri:regionArea><wicri:noRegion>Spain</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Chronic Disease Program, Institute of Health Carlos III, Madrid, Spain, mcalero@fundacioncien.es.</nlm:affiliation><country wicri:rule="url">Espagne</country><wicri:regionArea>Chronic Disease Program, Institute of Health Carlos III, Madrid, Spain</wicri:regionArea><wicri:noRegion>Spain</wicri:noRegion></affiliation></author></analytic><series><title level="j">Gerontology</title><idno type="eISSN">1423-0003</idno><imprint><date when="2021" type="published">2021</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>The older population has been especially affected by the severe acute respiratory syndrome coronavirus 2 pandemic (COVID-19).</p></div><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>The aim of the study was to explore the incidence, severity, mortality rate, clinical features, and risk factors of symptoms of COVID-19 in home-dwelling older people, and its association with type of residence, cognitive deterioration, and neurodegenerative diseases.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Data about symptoms of COVID-19 were collected through a telephone survey in the cohort of 913 older volunteers of the Vallecas Project, aged 75-90 years, most of them (902) home-dwelling, in Madrid, Spain. The association of demographic and anthropometric measures, genetic polymorphisms, comorbidities, life habits, type of residence, and frailty surrogates were explored as potential risk factors for the incidence, severity, and mortality of COVID-19 in the older population.</p></div><div type="abstract" xml:lang="en"><p><b>FINDINGS</b></p><p>Sixty-two cases reported symptoms compatible with COVID-19; 6 of them had died, 4 in their home and 2 in the nursing home. Moderate/severe cases were significantly older and more frequently males. The APOE ε4 allele was associated with the presence of symptoms of COVID-19. Higher systolic blood pressure, more intense smoking habit, more alcohol intake, lower consumption of coffee and tea, and cognitive impairment were associated with disease severity.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>The estimated incidence of symptomatic COVID-19 in this older cohort of Madrid was 6.8%, with an overall mortality rate of 0.7% (18.2% in those living in a nursing home) and a fatality rate of 9.9%. Our exploratory study indicates that life habits, other clinical conditions and, the ε4 variant of the APOE gene are associated with the presence and clinical severity of coronavirus infection.</p></div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">33429394</PMID><DateRevised><Year>2021</Year><Month>01</Month><Day>11</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1423-0003</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2021</Year><Month>Jan</Month><Day>11</Day></PubDate></JournalIssue><Title>Gerontology</Title><ISOAbbreviation>Gerontology</ISOAbbreviation></Journal><ArticleTitle>Residence, Clinical Features, and Genetic Risk Factors Associated with Symptoms of COVID-19 in a Cohort of Older People in Madrid.</ArticleTitle><Pagination><MedlinePgn>1-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1159/000513182</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The older population has been especially affected by the severe acute respiratory syndrome coronavirus 2 pandemic (COVID-19).</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">The aim of the study was to explore the incidence, severity, mortality rate, clinical features, and risk factors of symptoms of COVID-19 in home-dwelling older people, and its association with type of residence, cognitive deterioration, and neurodegenerative diseases.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Data about symptoms of COVID-19 were collected through a telephone survey in the cohort of 913 older volunteers of the Vallecas Project, aged 75-90 years, most of them (902) home-dwelling, in Madrid, Spain. The association of demographic and anthropometric measures, genetic polymorphisms, comorbidities, life habits, type of residence, and frailty surrogates were explored as potential risk factors for the incidence, severity, and mortality of COVID-19 in the older population.</AbstractText><AbstractText Label="FINDINGS" NlmCategory="RESULTS">Sixty-two cases reported symptoms compatible with COVID-19; 6 of them had died, 4 in their home and 2 in the nursing home. Moderate/severe cases were significantly older and more frequently males. The APOE ε4 allele was associated with the presence of symptoms of COVID-19. Higher systolic blood pressure, more intense smoking habit, more alcohol intake, lower consumption of coffee and tea, and cognitive impairment were associated with disease severity.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The estimated incidence of symptomatic COVID-19 in this older cohort of Madrid was 6.8%, with an overall mortality rate of 0.7% (18.2% in those living in a nursing home) and a fatality rate of 9.9%. Our exploratory study indicates that life habits, other clinical conditions and, the ε4 variant of the APOE gene are associated with the presence and clinical severity of coronavirus infection.</AbstractText><CopyrightInformation>© 2021 S. Karger AG, Basel.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Del Ser</LastName><ForeName>Teodoro</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Alzheimer's Disease Investigation Research Unit, CIEN Foundation, Institute of Health Carlos III, Queen Sofia Foundation Alzheimer Research Center, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fernández-Blázquez</LastName><ForeName>Miguel A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Alzheimer's Disease Investigation Research Unit, CIEN Foundation, Institute of Health Carlos III, Queen Sofia Foundation Alzheimer Research Center, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Valentí</LastName><ForeName>Meritxell</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Alzheimer's Disease Investigation Research Unit, CIEN Foundation, Institute of Health Carlos III, Queen Sofia Foundation Alzheimer Research Center, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zea-Sevilla</LastName><ForeName>María Ascensión</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Alzheimer's Disease Investigation Research Unit, CIEN Foundation, Institute of Health Carlos III, Queen Sofia Foundation Alzheimer Research Center, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Frades</LastName><ForeName>Belén</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Alzheimer's Disease Investigation Research Unit, CIEN Foundation, Institute of Health Carlos III, Queen Sofia Foundation Alzheimer Research Center, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alfayate</LastName><ForeName>Eva</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Alzheimer's Disease Investigation Research Unit, CIEN Foundation, Institute of Health Carlos III, Queen Sofia Foundation Alzheimer Research Center, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Saiz</LastName><ForeName>Laura</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Alzheimer's Disease Investigation Research Unit, CIEN Foundation, Institute of Health Carlos III, Queen Sofia Foundation Alzheimer Research Center, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Calero</LastName><ForeName>Olga</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Centro de Investigación Biomédica en Red sobre Enfermedades Degenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Chronic Disease Program, Institute of Health Carlos III, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>García-López</LastName><ForeName>Fernando José</ForeName><Initials>FJ</Initials><AffiliationInfo><Affiliation>National Epidemiology Centre, Institute of Health Carlos III, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rábano</LastName><ForeName>Alberto</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Alzheimer's Disease Investigation Research Unit, CIEN Foundation, Institute of Health Carlos III, Queen Sofia Foundation Alzheimer Research Center, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Medina</LastName><ForeName>Miguel</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Alzheimer's Disease Investigation Research Unit, CIEN Foundation, Institute of Health Carlos III, Queen Sofia Foundation Alzheimer Research Center, Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centro de Investigación Biomédica en Red sobre Enfermedades Degenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Calero</LastName><ForeName>Miguel</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Alzheimer's Disease Investigation Research Unit, CIEN Foundation, Institute of Health Carlos III, Queen Sofia Foundation Alzheimer Research Center, Madrid, Spain, mcalero@fundacioncien.es.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centro de Investigación Biomédica en Red sobre Enfermedades Degenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain, mcalero@fundacioncien.es.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Chronic Disease Program, Institute of Health Carlos III, Madrid, Spain, mcalero@fundacioncien.es.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2021</Year><Month>01</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Gerontology</MedlineTA><NlmUniqueID>7601655</NlmUniqueID><ISSNLinking>0304-324X</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">APOE gene</Keyword><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">Clinical features</Keyword><Keyword MajorTopicYN="N">Cognitive impairment</Keyword><Keyword MajorTopicYN="N">Incidence</Keyword><Keyword MajorTopicYN="N">Madrid</Keyword><Keyword MajorTopicYN="N">Mortality</Keyword><Keyword MajorTopicYN="N">Nursing home</Keyword><Keyword MajorTopicYN="N">Older people</Keyword><Keyword MajorTopicYN="N">Risk factors</Keyword><Keyword MajorTopicYN="N">Vallecas Project</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>07</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>11</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2021</Year><Month>1</Month><Day>11</Day><Hour>20</Hour><Minute>17</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2021</Year><Month>1</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2021</Year><Month>1</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33429394</ArticleId><ArticleId IdType="pii">000513182</ArticleId><ArticleId IdType="doi">10.1159/000513182</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Espagne</li></country><region><li>Communauté de Madrid</li></region><settlement><li>Madrid</li></settlement></list><tree><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Del Ser, Teodoro" sort="Del Ser, Teodoro" uniqKey="Del Ser T" first="Teodoro" last="Del Ser">Teodoro Del Ser</name></region><name sortKey="Alfayate, Eva" sort="Alfayate, Eva" uniqKey="Alfayate E" first="Eva" last="Alfayate">Eva Alfayate</name><name sortKey="Calero, Miguel" sort="Calero, Miguel" uniqKey="Calero M" first="Miguel" last="Calero">Miguel Calero</name><name sortKey="Calero, Miguel" sort="Calero, Miguel" uniqKey="Calero M" first="Miguel" last="Calero">Miguel Calero</name><name sortKey="Calero, Miguel" sort="Calero, Miguel" uniqKey="Calero M" first="Miguel" last="Calero">Miguel Calero</name><name sortKey="Calero, Olga" sort="Calero, Olga" uniqKey="Calero O" first="Olga" last="Calero">Olga Calero</name><name sortKey="Calero, Olga" sort="Calero, Olga" uniqKey="Calero O" first="Olga" last="Calero">Olga Calero</name><name sortKey="Fernandez Blazquez, Miguel A" sort="Fernandez Blazquez, Miguel A" uniqKey="Fernandez Blazquez M" first="Miguel A" last="Fernández-Blázquez">Miguel A. Fernández-Blázquez</name><name sortKey="Frades, Belen" sort="Frades, Belen" uniqKey="Frades B" first="Belén" last="Frades">Belén Frades</name><name sortKey="Garcia L Pez, Fernando Jose" sort="Garcia L Pez, Fernando Jose" uniqKey="Garcia L Pez F" first="Fernando José" last="García-L Pez">Fernando José García-L Pez</name><name sortKey="Medina, Miguel" sort="Medina, Miguel" uniqKey="Medina M" first="Miguel" last="Medina">Miguel Medina</name><name sortKey="Medina, Miguel" sort="Medina, Miguel" uniqKey="Medina M" first="Miguel" last="Medina">Miguel Medina</name><name sortKey="Rabano, Alberto" sort="Rabano, Alberto" uniqKey="Rabano A" first="Alberto" last="Rábano">Alberto Rábano</name><name sortKey="Saiz, Laura" sort="Saiz, Laura" uniqKey="Saiz L" first="Laura" last="Saiz">Laura Saiz</name><name sortKey="Valenti, Meritxell" sort="Valenti, Meritxell" uniqKey="Valenti M" first="Meritxell" last="Valentí">Meritxell Valentí</name><name sortKey="Zea Sevilla, Maria Ascensi N" sort="Zea Sevilla, Maria Ascensi N" uniqKey="Zea Sevilla M" first="María Ascensi N" last="Zea-Sevilla">María Ascensi N Zea-Sevilla</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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